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Pragmatic Play Free Trial
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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often described as focusing on practical aspects of study design, including recruitment and consent, adherence and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from various geographical areas. This type of heterogeneity, which is vital for pragmatic trials to be valid and reduce bias in results is also essential. Too much heterogeneity, however could cause issues with the design of the trial.
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Legality
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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum credibility externally. They are usually requested by practitioners and policymakers to inform their decisions. They are also a good way to identify the cause-effect relationship between the intervention and its effects. However, they should not, be used to replace explanatory studies.
The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which guide the policy and practice of. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool was designed to define the elements of a pragmatic study, including recruitment, design and delivery of the intervention, and the follow-up.
The number of pragmatic trials is growing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority were conducted in primary-care settings.